There is a two-way street between your immune system and sleep. When our immune system is activated to fight an infection or there is some type of chronic inflammation, it affects our sleep. The opposite is also true, our sleep quantity and quality affects how our immune system functions.
Think about the last time you were sick with a cold or a flu. Did you feel tired- like you needed to sleep it off? For an acute infectious situation, the inflammation triggered by the immune system tends to increase sleep duration and intensity. There is typically an increase in slow wave or deep sleep (or deep sleep) in response to infection. When we are sick and we get some sleep, it does decrease those inflammatory proteins set into action by the virus. It helps with resolution of the immune response in a way. This is perhaps why when we do not pay attention to our self-care when sick and get adequate rest, it seems like the symptoms persist longer. It perhaps is not that the infection does not resolve but the immune system aftermath is what persists. It is important to listen to your body and rest as sleep seems to help reduce the inflammation in response to the infection.
Sleep quantity and quality also affects our ability to fight off infections in the first place. Adequate sleep reduces the infection risk as well as improves infection outcome. Adequate sleep has also been shown to give better response rates to vaccines. Chronic sleep deprivation (less than 6 hours per night) leads to chronic inflammation and a depression of the immune system response. Part of why this happens is our body is always trying to balance things out. With chronic low grade inflammation, we have an increased risk of infection. When it comes to sleep, the “right amount” seems to be 7-8 hours. Less than that we are at greater risk of infection and chronic inflammation and believe it or not sleeping more than that also carries health risk.
During our lifetime, we are exposed to viruses and bacteria that in a way stay with us and can be a low-level infection and causes chronic inflammation. Overtime, the inflammatory proteins can be overwhelming to our system and conversely, decreased ability to fall asleep and stay asleep can occur. One of the more common “hot spots” for these low level infections is in the gut. Our gut bacteria can contribute to chronic inflammation and affect our sleep. That is why we sometimes look at the stool testing in functional medicine in cases of insomnia as well as other potential stealth infections such as Epstein Bar Virus, Herpes virus and Tick Borne Infections.
The Sleep–Immune Crosstalk in Health and Disease.
Besedovsky L, Lange T, Haack M.
Physiol Rev. 2019 Jul 1;99(3):1325-1380. doi: 10.1152/physrev.00010.2018. Review.
The Bidirectional Relationship between Sleep and Immunity against Infections.
Ibarra-Coronado EG, Pantaleón-Martínez AM, Velazquéz-Moctezuma J, Prospéro-García O, Méndez-Díaz M, Pérez-Tapia M, Pavón L, Morales-Montor J.
J Immunol Res. 2015;2015:678164. doi: 10.1155/2015/678164. Epub 2015 Aug 31. Review.
Sleep Health: Reciprocal Regulation of Sleep and Innate Immunity.
Irwin MR, Opp MR.
Neuropsychopharmacology. 2017 Jan;42(1):129-155. doi: 10.1038/npp.2016.148. Epub 2016 Aug 11. Review.