There is rebound weight gain upon discontinuation of GLP-1 medications. This is the reality of the data. So when I hear about the widespread use of the medication, and the fact that many patients who start a GLP-1 medication discontinue use after 1-2 years, we need to have this conversation about not if but when you stop the GLP-1 medication.

Semaglutide is a GLP-1 agonist. This is a mimic of a hormone naturally produced and helps us feel full and satiated. Until now all GLP-1 medications for weight loss that are commercially available have been injections.